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SCIENCE

The science-backed advantages of Coeliac Safe liposomal supplements include higher bioavailability of the nutrient, protection of the gut from potential irritation and accelerated intestinal absorption.

What is high bioavailability and absorption?

Absorption is when the small intestine breaks down nutrients that are then absorbed into the bloodstream and the circulatory system carries and transfers them to cells throughout the body where the nutrients either stored or used.

Bioavailability refers to the extent and rate absorption occurs.

Macronutrients (fat, protein, and carbohydrates) are highly bioavailable. However, micronutrients (vitamins and minerals) in supplements can often be harder for the body to absorb.

Selecting highly bioavailable supplements increases the chances of your body absorbing essential micronutrients.

Bioavailability graphic visual 5.png

Supplement

Absorption

GI tract 

Distribution

From blood to tissues

Metabolism

Mostly hepatic

Excretion

What is bioavailability and absorption

The problem

 

When regular, lower quality, vitamin and mineral supplements are taken orally, most do not reach the bloodstream because they are broken down and dissolved through digestion, metabolism, and excretion. Therefore, they are unable to be fully absorbed by the digestive system. There are several factors that can affect bioavailability and absorption including:

Digestive componentsstomach acid, bile and digestive enzymes can break down regular vitamin and mineral supplements, impacting the percentage of the supplement being absorbed into the bloodstream.

Damage to your gut people with coeliac disease may have damage to the lining of the gut. This can affect the absorption of micronutrients from supplements as well as from food.

The supplement formulation many regular vitamin supplements contain poor quality ingredients, excipients, binders, fillers, and flow agents that can contribute to poor absorption.

The delivery method for instance: capsules are likely to be more effective than tablets. Tablets are more likely to break down inconsistently. The uneven disintegration can decrease the effectiveness and absorption of the supplement.

How and when you take the supplementwhether the supplement is taken with food or water and the time of day taken, can all affect absorption.

Interactions with other supplements in your system - for instance: taking calcium and iron at the same time can impair their absorption.

The problem and solution

Bioavailability percentage

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The solution

How do Coeliac Safe liposomal supplements improve nutrient absorption?

 

Liposomes deliver the micronutrients (the vitamins or minerals) into the body effectively by protecting them in a biocompatible bubble of phospholipids (which are fat molecules that make up the main part of the human cell wall). This prevents the breakdown from stomach acid and therefore, the liposomes successfully reach the small intestine where they can be fully absorbed into the circulatory system and distributed around the body.

 

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Micronutrients

The phospholipid bilayer

The structure of liposomes

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Liposome 2D - Fusing with cell.png

Whilst in the bloodstream, the liposomes fuse with the cell walls and the active ingredients are released (allowing them to be absorbed directly into the cells and not just into the bloodstream). This results in significantly higher bioavailability and absorption.

Liposome

Cell

Liposome fuses with the cell

The active ingredients are released

The active ingredients are absorbed directly into the cells

Liposomes are non-toxic, biocompatible, and fully biodegradable. They provide 8 times greater bioavailability and sustainability of blood levels of the active ingredient.

The liposomal form of our supplements prevents compatibility issues with taking multiple vitamins at the same time. This is because the active ingredient is enclosed in the liposome bubble, preventing the interaction with other supplements.

The liposomal form of our supplements also prevents stomach upset, nausea and constipation that’s sometimes connected to conventional supplementation, especially Iron. This is because the iron is enclosed in the liposome bubble, preventing the interaction with the stomach and intestines.

The solution bioavailability graphic visual 2.png

Bioavailability percentage

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Studies of liposomal products

Studies of liposomal products

Study with powdered vitamin B12

A single-dose, crossover study was conducted in six human subjects of equivalent doses of two dosage forms of vitamin B12:

 

  1. Coeliac Safe liposomal powder-filled capsule (LipoCellTech™ technology).

  2. Traditional liposomal liquid

 

Each subject was given 3 mg of (A) in one dosage form, followed by a washout period of 14 days, then each subject was given 3 mg of (B).

All subjects (with one exception) had an increase above baseline at one or more time points over 135 minutes. Serum B12 increased six-fold on average after taking the Coeliac Safe capsule (LipoCellTech™ technology). This was significantly more compared to (B) the traditional liposomal liquid when comparing the highest peak of each subject’s serum B12.

B12 tablet vs traditional liposome vs Coeliac Safe liposome

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liposome

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Fig 1: Increase in vitamin D level after 30 days (%)

Vitamin D Graph 1.png

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liposome

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Fig 2: Vitamin D - insufficient baseline (<30 ng/ mL)

Vitamin D Study

The Effect of a Liposomal Cholecalciferol Preparation on 25(OH)*

(Vitamin D Levels – A comparative, open-label study)

 

*25 OH is referring to the following: your body converts vitamin D to a chemical known as  25-hydroxyvitamin D, also called calcidiol. The 25-hydroxy vitamin D test is the best way to monitor vitamin D levels. The amount of 25-hydroxyvitamin D in your blood is a good indication of how much vitamin D your body has.

Abstract: Fifteen healthy participants underwent baseline 25(OH) Vitamin D testing, followed by supplementation with a liposomal product containing 125 mcg (5,000 IU) vitamin D and 400 mcg vitamin K (as MK7) daily for 30 days. Participants in this study had an average increase in serum 25(OH) Vitamin D of 73% over baseline. (Fig 1)

For comparison, the average increase in 25(OH) Vitamin D with supplementation of a non-liposomal preparation for 30 days at this dosage is 16%. Individuals who began the study with a 25(OH) Vitamin D level in the “insufficient” range (below 30 ng/mL) had an even greater response, averaging a 112% increase. (Fig 2)

Conclusion: Supplementation with a liposomal vitamin D product for 30 days resulted in a much greater increase in serum 25(OH) Vitamin D than typical results after supplementation with a non-liposomal preparation (average 73% vs 16%), proving the superior absorption of liposomal Vitamin D.

Vitamin C Study

PART 1: How much Liposomal Vitamin C absorbs into a person’s blood (bioavailability)?

Figure 1 shows that, compared with “normal” Vitamin C ingestion (single dose of 4 g), ingestion of Liposomal Vitamin C (also 4 g) leads to appreciably greater circulating Vitamin C concentrations. Hence, liposomes facilitate Vitamin C delivery to the blood.

PART 2: What will Vitamin C do once in the blood (efficacy)?

The next step in the study is to determine if the Vitamin C concentration is meaningful.  In this regard, an ischemia reperfusion study was performed.  Ischemia describes any tissue that has been deprived of blood and oxygen.

Reperfusion occurs when the blood and oxygen supply is returned.  Unfortunately, reperfusion can cause massive oxidative stress on your cardiovascular system, as the oxygen interacts with metabolites produced by the oxygen-deprived tissues.  Per the blue line in the diagram here, oxidative stress was reduced even during the increased oxidative stress of reperfusion. [1]

 

Vitamin C Graph 1.png

Regular vitamin C

Liposomal vitamin C

Placebo

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Plasma vitamin C concentration (mg/dL)

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Time (Hours)

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Oxidative Stress

Base

Pre-cuff

Post-cuff

Liposomal vitamin C

Placebo

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Photo of a single LipoCellTech™ powdered liposome after contact with body fluids. The phospholipids are on the outside and the ingredients in the middle. Magnified 30,000 X with an electron microscope. 

References

[1] 3. Davis, J. L., Paris, H. L., Beals, J. W., Binns, S. E., Giordano, G. R., Scalzo, R. L., Schweder, M. M., Blair, E., & Bell, C. (2016). Liposomal-encapsulated Ascorbic Acid: Influence on Vitamin C Bioavailability and Capacity to Protect Against Ischemia-Reperfusion Injury. Nutrition and metabolic insights, 9, 25–30. https://doi.org/10.4137/NMI.S39764.

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